Structure of PDB 4pme Chain A

Receptor sequence

>4pmeA (length=117) Species: 9606 (Homo sapiens)

KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGL
TTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIA
ALLSPYSYSTTAVVTNP

3D structure

• PDB: 4pme Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures.
• Chain: A
• Resolution: 1.264 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CUR	A	K15 L17 P24 S52 S117 T118 T119	K7 L9 P16 S44 S109 T110 T111
BS02	EDO	A	L110 S112 S115 Y116	L102 S104 S107 Y108

Gene Ontology

Molecular Function

• GO:0005179 hormone activity
• GO:0005515 protein binding
• GO:0042802 identical protein binding
• GO:0070324 thyroid hormone binding

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0007165 signal transduction

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0035578 azurophil granule lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:4pme, PDBe:4pme, PDBj:4pme
• PDBsum: 4pme
• PubMed: 25224922
• UniProt: P02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)