Structure of PDB 4pla Chain A

Receptor sequence
>4plaA (length=483) Species: 9606,10665 [Search protein sequence]
RNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAV
FKPKNEEPYGHLNPKWTKWLQKGTGNIFEMLRIDEGLRLKIYKDTEGYYT
IGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVR
GILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRW
DEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNLGRDCLVLNQGYL
SEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRIGLPPKVGS
FQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDR
GNDNWLIKYDDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLP
QAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQI
AVMRGQILNLTQALKDNKSPLHLVQMPPVIVET
3D structure
PDB4pla The crystal structure of the phosphatidylinositol 4-kinase II alpha.
ChainA
Resolution2.771 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1013 D1022
Catalytic site (residue number reindexed from 1) E85 D94
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A W359 P363 F364 W368 V444 Q445 W389 P393 F394 W398 V474 Q475
BS02 ATP A G133 S134 S137 V150 K152 Q261 F263 V264 I345 D346 G33 S34 S37 V50 K52 Q302 F304 V305 I375 D376
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004430 1-phosphatidylinositol 4-kinase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pla, PDBe:4pla, PDBj:4pla
PDBsum4pla
PubMed25168678
UniProtD9IEF7;
Q9BTU6|P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (Gene Name=PI4K2A)

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