Structure of PDB 4pks Chain A

Receptor sequence
>4pksA (length=486) Species: 1392 (Bacillus anthracis) [Search protein sequence]
RYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEK
ELLKRIQIDSSDFLSTEEKEFLKKLQIDIEKEKEFLKKLKLDIQPYDINQ
RLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYEN
MNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINE
RPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEK
EYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNR
YASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIA
EQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGH
AVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEA
FRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
3D structure
PDB4pks Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H396 E397 H400 Y438 E445
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H686 H690 E735 H396 H400 E445
BS02 30H A F329 S655 K656 G657 L677 H686 E687 H690 Y728 E735 E739 R742 F63 S365 K366 G367 L387 H396 E397 H400 Y438 E445 E449 R452 MOAD: ic50=15.2uM
PDBbind-CN: -logKd/Ki=4.82,IC50=15.2uM
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:4pks, PDBe:4pks, PDBj:4pks
PDBsum4pks
PubMed25372673
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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