Structure of PDB 4pk2 Chain A

Receptor sequence
>4pk2A (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
FTMEFPFDVDALFPERITVLDQHLRPPAVDLQQQIMTIIDELGKASAKAQ
NLSAPITSASRMQSNRHVVYILKDSSARPAGKGAIIGFIKVGYKKLFVLD
DREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDR
PSQKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHPP
3D structure
PDB4pk2 Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.108: alpha-tubulin N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q58 I64 K102 L122 D123 D157 N182 F183 Q50 I56 K94 L114 D115 D149 N174 F175
BS02 COA A Q58 F124 Y125 I126 Q131 R132 G134 G136 R137 S160 K162 K165 F166 K169 Q50 F116 Y117 I118 Q123 R124 G126 G128 R129 S152 K154 K157 F158 K161
Gene Ontology
Molecular Function
GO:0019799 tubulin N-acetyltransferase activity
Biological Process
GO:0071929 alpha-tubulin acetylation
Cellular Component
GO:0005874 microtubule

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Cellular Component
External links
PDB RCSB:4pk2, PDBe:4pk2, PDBj:4pk2
PDBsum4pk2
PubMed24906155
UniProtQ5SQI0|ATAT_HUMAN Alpha-tubulin N-acetyltransferase 1 (Gene Name=ATAT1)

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