Structure of PDB 4pjl Chain A

Receptor sequence

>4pjlA (length=760) Species: 9823 (Sus scrofa)

KPVWAPHPTDGFQVGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEED
SKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIP
KIYSSETIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKLSQSIIVSGESG
AGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSS
RFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAG
ASEDIRERLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAG
SLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEE
AGSTSGGCNLKNKSTQALEYCAELLGLDQDDLRVSLTTRVMVIKVPLKVE
QANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIEGFEYFE
HNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDC
IDLIEARLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLSIPRKSK
LAIHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRD
KFIRELFELSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHH
FEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMPDKLARL
DPRLFCKALFKALGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAE
LVKRVNHWLI

3D structure

• PDB: 4pjl How actin initiates the motor activity of Myosin.
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S153 G154 T158 N200 S203 S204 G459 E461
• Catalytic site (residue number reindexed from 1): S149 G150 T154 N196 S199 S200 G445 E447

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	T158 S204	T154 S200
BS02	ADP	A	N98 P99 G154 G156 K157 T158 E159 N200	N94 P95 G150 G152 K153 T154 E155 N196

Gene Ontology

Molecular Function

• GO:0003774 cytoskeletal motor activity
• GO:0005524 ATP binding
• GO:0051015 actin filament binding

Cellular Component

• GO:0016459 myosin complex

External links

• PDB: RCSB:4pjl, PDBe:4pjl, PDBj:4pjl
• PDBsum: 4pjl
• PubMed: 25936506
• UniProt: F1RQI7