Structure of PDB 4ph7 Chain A

Receptor sequence
>4ph7A (length=401) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
IDTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVT
NQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGE
YFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSR
FLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRI
ELGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGK
WNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKK
VTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGE
DLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQ
K
3D structure
PDB4ph7 INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2Y5 A L64 T65 R66 L69 I73 M79 Q86 K125 K126 N129 H157 H158 S183 S190 A191 A192 Q219 V222 V224 I227 K351 E355 R359 L30 T31 R32 L35 I39 M45 Q52 K91 K92 N95 H123 H124 S149 S156 A157 A158 Q185 V188 V190 I193 K317 E321 R325
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005548 phospholipid transporter activity
GO:0008289 lipid binding
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0032934 sterol binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0070300 phosphatidic acid binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
GO:0120015 sterol transfer activity
Biological Process
GO:0006869 lipid transport
GO:0006887 exocytosis
GO:0006897 endocytosis
GO:0015914 phospholipid transport
GO:0015918 sterol transport
GO:0016125 sterol metabolic process
GO:0030011 maintenance of cell polarity
GO:0034727 piecemeal microautophagy of the nucleus
GO:0055092 sterol homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ph7, PDBe:4ph7, PDBj:4ph7
PDBsum4ph7
PubMed26206936
UniProtQ02201|OSH6_YEAST Oxysterol-binding protein homolog 6 (Gene Name=OSH6)

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