Structure of PDB 4pfy Chain A

Receptor sequence

>4pfyA (length=539) Species: 243274 (Thermotoga maritima MSB8)

TFERNKTLYWGGALWSPPSNWNPFTPWNAVAGTIGLVYEPLFLYDPLNDK
FEPWLAEKGEWVSNNEYVLTLRKGLRWQDGVPLTADDVVFTFEIAKKYTG
ISYSPVWNWLGRIERVDERTLKFVFSDPRYQEWKQMLINTPIVPKHIWEN
KTEEEVLQAANENPVGSGPYYVESWADDRCVFKKNGNWWGIRELGYDPKP
ERIVELRVLSNNVAVGMLMKGELDWSNFFLPGVPVLKKAYGIVTWYENAP
YMLPANTAGIYINVNKYPLSIPEFRRAMAYAINPEKIVTRAYENMVTAAN
PAGILPLPGYMKYYPKEVVDKYGFKYDPEMAKKILDELGFKDVNKDGFRE
DPNGKPFKLTIECPYGWTDWMVSIQSIAEDLVKVGINVEPKYPDYSKYAD
DLYGGKFDLILNNFTTGVSATIWSYFNGVFYPDAVESEYSYSGNFGKYAN
PEVETLLDELNRSNDDAKIKEVVAKLSEILLKDLPFIPLWYNGAWFQASE
AVWTNWPTEKNPYAVPIGWNGWWQLTGIKTLFGIEAKHH

3D structure

• PDB: 4pfy Duplication of Genes in an ATP-binding Cassette Transport System Increases Dynamic Range While Maintaining Ligand Specificity.
• Chain: A
• Resolution: 1.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	A	S122 Y123 E152 Y451 S462	S102 Y103 E132 Y431 S442
BS02	BMA	A	S122 N159 S462	S102 N139 S442
BS03	BMA	A	Y423 F434 Y461	Y403 F414 Y441
BS04	BMA	A	F434 N540 W542	F414 N520 W522
BS05	BMA	A	W387 N433 F434 W539	W367 N413 F414 W519
BS06	BMA	A	N231 N247 F248 F249 W387 D389 W390 W515	N211 N227 F228 F229 W367 D369 W370 W495
BS07	MG	A	D362 N364 D366 F368 E370	D342 N344 D346 F348 E350

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding
• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:4pfy, PDBe:4pfy, PDBj:4pfy
• PDBsum: 4pfy
• PubMed: 25210043
• UniProt: Q9X0V0