Structure of PDB 4pfd Chain A

Receptor sequence

>4pfdA (length=427) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]

TTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGL
GRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAAL
PFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADG
EIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVT
ASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQL
PAKLRSEPLKFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMAYGPAGFLQ
YQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGW
NICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRV
DEWISVRRKVDPLRVFASDMARRLELL

3D structure

PDB

4pfd Crystal structure of M. tuberculosis in complex with a cBT

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.98.3: decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	W16 A53 R54 G55 L56 G57 R58 S59 Y60 N63 P116 G117 T118 V121 T122 G124 G125 A128 C129 I131 H132 N178 G179 I184 Y415	W10 A47 R48 G49 L50 G51 R52 S53 Y54 N57 P110 G111 T112 V115 T116 G118 G119 A122 C123 I125 H126 N172 G173 I178 Y381
BS02	2R2	A	Y60 H132 K134 S228 Y314 L317 Q334 Q336 L363 V365 N385 C387 K418	Y54 H126 K128 S222 Y286 L289 Q300 Q302 L329 V331 N351 C353 K384

Gene Ontology

	Molecular Function
GO:0003885	D-arabinono-1,4-lactone oxidase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

	Biological Process
GO:0035884	arabinan biosynthetic process
GO:0045227	capsule polysaccharide biosynthetic process
GO:0046677	response to antibiotic
GO:0070592	cell wall polysaccharide biosynthetic process
GO:0071555	cell wall organization

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042597	periplasmic space

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4pfd, PDBe:4pfd, PDBj:4pfd
PDBsum	4pfd
PubMed
UniProt	P9WJF1\|DPRE1_MYCTU Decaprenylphosphoryl-beta-D-ribose oxidase (Gene Name=dprE1)

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