Structure of PDB 4pae Chain A

Receptor sequence
>4paeA (length=707) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]
HGGATTVNISTAEWWPKALNLDILSQHDRKTNPMGPDFNYQEEVKKLDVA
ALKQDLQALMTDSQDWFPADWGHYGGLMIRLTWHAAGTYRIADGRGGAGT
GNQRFAPLNSWPDNTNLDKARRLLWPIKQKYGNKLSWADLIAYAGTIAYE
SMGLKTFGFAFGREDIWHPEKDIYWGPEKEWVPPSTNPNSRYTGDRELEN
PLAAVTMGLIYVNPEGVDGNPDPLKTAHDVRVTFARMAMNDEETVALTAG
GHTVGKCHGNGNAALLGPEPEGADVEDQGLGWINKTQSGIGRNAVTSGLE
GAWTPHPTQWDNGYFRMLLNYDWELKKSPAGAWQWEPINPREEDLPVDVE
DPSIRRNLVMTDADMAMKMDPEYRKISERFYQDPAYFADVFARAWFKLTH
RDMGPKARYIGPDVPQEDLIWQDPIPAGNRNYDVQAVKDRIAASGLSISE
LVSTAWDSARTYRNSDKRGGANGARIRLAPQKDWEGNEPDRLAKVLAVLE
GIAAATGASVADVIVLAGNVGVEQAARAAGVEIVLPFAPGRGDATAEQTD
TESFAVLEPIHDGYRNWLKQDYAATPEELLLDRTQLLGLTAPEMTVLIGG
LRVLGTNHGGTKHGVFTDREGVLTNDFFVNLTDMNYLWKPAGKNLYEICD
RKTNQVKWTATRVDLVFGSNSILRAYSELYAQDDNKEKFVRDFVAAWTKV
MNADRFD
3D structure
PDB4pae Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid.
ChainA
Resolution3.206 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R91 H95 H263 W314 D375
Catalytic site (residue number reindexed from 1) R80 H84 H252 W303 D364
Enzyme Commision number 1.11.1.21: catalase peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEB A G87 L88 I90 W94 F245 L258 G262 H263 K267 C268 H269 T307 S308 W314 W406 G76 L77 I79 W83 F234 L247 G251 H252 K256 C257 H258 T296 S297 W303 W395
BS02 NIZ A F78 A80 D81 L88 H269 F67 A69 D70 L77 H258
Gene Ontology
Molecular Function
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006979 response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0070301 cellular response to hydrogen peroxide
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4pae, PDBe:4pae, PDBj:4pae
PDBsum4pae
PubMed25479089
UniProtQ31MN3|KATG_SYNE7 Catalase-peroxidase (Gene Name=katG)

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