Structure of PDB 4p7u Chain A

Receptor sequence
>4p7uA (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
ALCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLE
TVCHDPKLPYHDFILEDAASPTCIMKEKKKPGETFFMCSCSSDECNDNII
FS
3D structure
PDB4p7u The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-beta receptor extracellular domain.
ChainA
Resolution1.502 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1PS A Q41 W65 F111 F126 Q16 W40 F86 F101
Gene Ontology
Molecular Function
GO:0005026 transforming growth factor beta receptor activity, type II
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p7u, PDBe:4p7u, PDBj:4p7u
PDBsum4p7u
PubMed26073093
UniProtP37173|TGFR2_HUMAN TGF-beta receptor type-2 (Gene Name=TGFBR2)

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