Structure of PDB 4p7a Chain A

Receptor sequence
>4p7aA (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
FVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVK
EGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLGFRGEALASISHVAHVT
ITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRK
ALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVD
NIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINH
RLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPESILERVQQHIESK
LLG
3D structure
PDB4p7a Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N38 A42 G67 I68 T82 S83 K84 R100 G101 A103 L104 N36 A40 G65 I66 T80 S81 K82 R86 G87 A89 L90
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair
Cellular Component
GO:0032300 mismatch repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p7a, PDBe:4p7a, PDBj:4p7a
PDBsum4p7a
PubMed26249686
UniProtP40692|MLH1_HUMAN DNA mismatch repair protein Mlh1 (Gene Name=MLH1)

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