Structure of PDB 4p6x Chain A

Receptor sequence
>4p6xA (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMALMAFALGWRSYRQSSANLLYFAP
DLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKVLLLLSTI
PKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSM
HEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFH
QK
3D structure
PDB4p6x Structures and mechanism for the design of highly potent glucocorticoids.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 R585 L589 M593 L596 E755 V50 R60 L64 M68 L71 E230
BS02 HCY A L563 N564 Q570 M604 F623 Y735 C736 T739 L38 N39 Q45 M79 F98 Y210 C211 T214 MOAD: Ki=91nM
PDBbind-CN: -logKd/Ki=7.04,Ki=91nM
BindingDB: Ki=30nM
External links
PDB RCSB:4p6x, PDBe:4p6x, PDBj:4p6x
PDBsum4p6x
PubMed24763108
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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