Structure of PDB 4p6t Chain A

Receptor sequence
>4p6tA (length=287) Species: 1404 (Priestia megaterium) [Search protein sequence]
KYRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPG
SDRNAAHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDP
SQSQIWSADFMGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNF
GATKEAPTLPTRDDVLNALKITQYDTPPWDMTSQNSFRNQLEGFINGPQL
HNRVHRWVGGQMGVVPTAPNDPVFFLHHANVDRIWAVWQIIHRNQNYQPM
KNGPFGQNFRDPMYPWNTTPEDVMNHRKLGYVYDIEL
3D structure
PDB4p6t Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H60 H69
Catalytic site (residue number reindexed from 1) H57 H66
Enzyme Commision number 1.14.18.1: tyrosinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YRL A H42 H60 H204 N205 H208 V218 H39 H57 H201 N202 H205 V215
BS02 CU A H42 H60 H69 H39 H57 H66
BS03 CU A H204 H208 H231 H201 H205 H228
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4p6t, PDBe:4p6t, PDBj:4p6t
PDBsum4p6t
PubMed25074014
UniProtB2ZB02

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