Structure of PDB 4p5b Chain A

Receptor sequence
>4p5bA (length=229) Species: 249586 (Streptomyces asoensis) [Search protein sequence]
IELRSDITVELVDSSASDLAVVKAARVSTAGEDANDGGSTRGLIRYLMRS
RHGSPFEHNSMTFLVRAPIFTVRHLMRHRTWSFNEESARYREVGAAFYVP
DATRLLREGKPGDYRYVGGSTDDHQQVVRSATRAYEVAFEEYQRLLDSGI
AREIARLVLPVSTYSVLYATCNARALMHFLSLRTHRPDAAYVSHPQREIE
MVAEQMETAWAKLMPVTHEAFTAFGRVSP
3D structure
PDB4p5b Crystal structure of a UMP/dUMP methylase PolB form Streptomyces cacaoi bound with 5-Br dUMP
ChainA
Resolution2.274 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A R86 H87 R88 H188 R193 H204 R77 H78 R79 H178 R183 H194
BS02 BRU A E94 S96 A97 R98 Y99 R166 E85 S87 A88 R89 Y90 R156
BS03 BRU A H83 R86 R193 H74 R77 R183
BS04 FAD A N93 E94 N84 E85
BS05 FAD A S33 H61 S63 N182 R184 S28 H52 S54 N172 R174
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4p5b, PDBe:4p5b, PDBj:4p5b
PDBsum4p5b
PubMed
UniProtC1IC19

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