Structure of PDB 4p5a Chain A

Receptor sequence
>4p5aA (length=226) Species: 249586 (Streptomyces asoensis) [Search protein sequence]
PRIELRSDITVELVDSSASDLAVVKAARVSTAGGSTRGLIRYLMRSRHGS
PFEHNSMTFLVRAPIFTVRHLMRHRTWSFNEESARYREVGAAFYVPDATR
LLRQEGKPGDYRYVGGSTDDHQQVVRSATRAYEVAFEEYQRLLDSGIARE
IARLVLPVSTYSVLYATCNARALMHFLSLRTHRPDAAYVSHPQREIEMVA
EQMETAWAKLMPVTHEAFTAFGRVSP
3D structure
PDB4p5a Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi with 5-Br UMP
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A R86 H87 R88 H188 L192 R193 H204 R73 H74 R75 H175 L179 R180 H191
BS02 5BU A E94 S96 A97 R98 R166 E81 S83 A84 R85 R153
BS03 5BU A R82 H83 R86 Y124 R193 R69 H70 R73 Y111 R180
BS04 FAD A N93 E94 N80 E81
BS05 FAD A H61 E66 T89 N182 R184 H48 E53 T76 N169 R171
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4p5a, PDBe:4p5a, PDBj:4p5a
PDBsum4p5a
PubMed
UniProtC1IC19

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