Structure of PDB 4p4t Chain A

Receptor sequence
>4p4tA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
QYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGV
ALPRRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNA
IAGEGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTL
IKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDL
VDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKI
FFENHPYFRDLLEEGKATVPSLAEKLTSELITHISKSLPLLENQIKETHQ
RITEELQKYGVKRKFLKERLARLTQARRRLAQFPG
3D structure
PDB4p4t Transient Dimerization of Human MxA Promotes GTP Hydrolysis, Resulting in a Mechanical Power Stroke.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A S80 S81 G82 K83 S84 S85 K248 D250 K279 C280 R281 G282 Q283 S37 S38 G39 K40 S41 S42 K197 D199 K228 C229 R230 G231 Q232 PDBbind-CN: -logKd/Ki=4.39,Kd=41.0uM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4p4t, PDBe:4p4t, PDBj:4p4t
PDBsum4p4t
PubMed25295396
UniProtP20591|MX1_HUMAN Interferon-induced GTP-binding protein Mx1 (Gene Name=MX1)

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