Structure of PDB 4p1r Chain A

Receptor sequence
>4p1rA (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
TSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTS
CFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL
ERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS
ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT
GSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD
EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPL
LKACRDNLSQWEKVIRGE
3D structure
PDB4p1r Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).
ChainA
Resolution2.243 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H519 H553 D554 D664 H78 H112 D113 D223
BS02 2KR A Y683 P702 M703 K708 E711 G715 Q716 F719 Y242 P261 M262 K267 E270 G274 Q275 F278 MOAD: ic50=4.1nM
PDBbind-CN: -logKd/Ki=8.39,IC50=4.1nM
BindingDB: IC50=4.1nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4p1r, PDBe:4p1r, PDBj:4p1r
PDBsum4p1r
PubMed24944747
UniProtQ9Y233|PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Gene Name=PDE10A)

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