Structure of PDB 4p10 Chain A

Receptor sequence
>4p10A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
SGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNA
SDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYH
SLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAI
WIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVN
VDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSC
SETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTR
SKSKDHEELSLVASEAVRAIEKTSKNTRYTYGQGSETLYLAPGGGDDWIY
DLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNVL
EP
3D structure
PDB4p10 Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa).
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H181 E184 R239 H310 E385
Catalytic site (residue number reindexed from 1) H157 E160 R215 H286 E361
Enzyme Commision number 3.4.17.20: carboxypeptidase U.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2B8 A H181 E184 N256 R257 H310 S311 Y312 S321 L362 D370 E385 H157 E160 N232 R233 H286 S287 Y288 S297 L338 D346 E361 PDBbind-CN: -logKd/Ki=8.10,IC50=8nM
BindingDB: IC50=8.0nM
BS02 ZN A H181 E184 H310 H157 E160 H286
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0009410 response to xenobiotic stimulus
GO:0010757 negative regulation of plasminogen activation
GO:0030163 protein catabolic process
GO:0042730 fibrinolysis
GO:0051918 negative regulation of fibrinolysis
GO:0071333 cellular response to glucose stimulus
GO:0097421 liver regeneration
GO:2000346 negative regulation of hepatocyte proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p10, PDBe:4p10, PDBj:4p10
PDBsum4p10
PubMed24588961
UniProtQ96IY4|CBPB2_HUMAN Carboxypeptidase B2 (Gene Name=CPB2)

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