Structure of PDB 4p0p Chain A

Receptor sequence
>4p0pA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
QQQPLELRPGEYRVLLCVDIGETRGPELLRELQRLHVTHTVRKLHVGDFV
WVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRC
GLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESA
AYLALLTRGLQRLYQGHTLRSRPWGTPGPNPLCSLLTFSDFNAGAIKNKA
QSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQET
LLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT
3D structure
PDB4p0p Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A I344 T383 Q386 A387 R530 N531 I85 T124 Q127 A128 R262 N263
BS02 dna A R483 S486 K489 R530 R215 S218 K221 R262
BS03 MG A D274 E277 D307 D19 E22 D48
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0008821 crossover junction DNA endonuclease activity
Biological Process
GO:0006302 double-strand break repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4p0p, PDBe:4p0p, PDBj:4p0p
PDBsum4p0p
PubMed24733841
UniProtQ96NY9|MUS81_HUMAN Crossover junction endonuclease MUS81 (Gene Name=MUS81)

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