Structure of PDB 4oys Chain A

Receptor sequence
>4oysA (length=553) Species: 9606 (Homo sapiens) [Search protein sequence]
LKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLK
CVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLR
QADDEDLLMYLLQLVQALKYENFDDIKNGLEPINSAEIDSSQIITSPLPN
LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNV
MRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKN
ERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQ
LFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPY
KVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDP
KPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLF
SLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHAL
FAA
3D structure
PDB4oys A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.
ChainA
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1TT A F612 P618 I634 Y670 M682 Q683 F684 I685 L750 I760 F292 P298 I314 Y350 M362 Q363 F364 I365 L430 I440 PDBbind-CN: -logKd/Ki=8.82,Kd=1.52nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4oys, PDBe:4oys, PDBj:4oys
PDBsum4oys
PubMed25326666
UniProtQ8NEB9|PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (Gene Name=PIK3C3)

[Back to BioLiP]