Structure of PDB 4oyo Chain A

Receptor sequence
>4oyoA (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISG
FTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDA
LLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIRVKIGLAAG
HISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRS
MIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLR
LACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLM
FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGF
PGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTV
RHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVM
KGVADSGPLYQYWGRTEK
3D structure
PDB4oyo Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1WC A D47 D99 R176 F338 D47 D99 R176 F338 PDBbind-CN: -logKd/Ki=3.52,IC50>300uM
BS02 1WC A F45 K95 L102 L166 V167 F336 M337 F338 F45 K95 L102 L166 V167 F336 M337 F338 PDBbind-CN: -logKd/Ki=3.52,IC50>300uM
BS03 1WC A T52 G98 V411 A415 T52 G98 V411 A415 PDBbind-CN: -logKd/Ki=3.52,IC50>300uM
Gene Ontology
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4oyo, PDBe:4oyo, PDBj:4oyo
PDBsum4oyo
PubMed24616449
UniProtQ96PN6|ADCYA_HUMAN Adenylate cyclase type 10 (Gene Name=ADCY10)

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