Structure of PDB 4owo Chain A

Receptor sequence
>4owoA (length=348) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMK
APTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMA
AIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEV
GIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCA
FADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKL
TFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAG
AIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
3D structure
PDB4owo Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
ChainA
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V106
Catalytic site (residue number reindexed from 1) V84
Enzyme Commision number 2.4.2.18: anthranilate phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D251 E252 D229 E230
BS02 MG A S119 E252 S97 E230
BS03 PRP A V106 G107 G109 G110 N117 S119 T120 K135 A140 A141 S142 S143 G146 V84 G85 G87 G88 N95 S97 T98 K113 A118 A119 S120 S121 G124
BS04 6F0 A N138 A179 P180 H183 Y186 A190 N116 A157 P158 H161 Y164 A168 PDBbind-CN: -logKd/Ki=4.47,Ki=34uM
BS05 6F0 A V106 G107 T108 H136 N138 R193 G206 V84 G85 T86 H114 N116 R171 G184 PDBbind-CN: -logKd/Ki=4.47,Ki=34uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004048 anthranilate phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000162 tryptophan biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4owo, PDBe:4owo, PDBj:4owo
PDBsum4owo
PubMed24712732
UniProtP9WFX5|TRPD_MYCTU Anthranilate phosphoribosyltransferase (Gene Name=trpD)

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