Structure of PDB 4ow3 Chain A

Receptor sequence
>4ow3A (length=314) Species: 1427 (Bacillus thermoproteolyticus) [Search protein sequence]
ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTL
PGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAI
RSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTD
YTAGLIYQNESGAINEAISDIFGTLVEFYANPDWEIGEDVYTPGISGDSL
RSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYG
VSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQE
VASVKQAFDAVGVK
3D structure
PDB4ow3 Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H142 E143 H146 Y157 E166 D226 H231
Catalytic site (residue number reindexed from 1) H142 E143 H146 Y157 E166 D224 H229
Enzyme Commision number 3.4.24.27: thermolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H142 H146 E166 H142 H146 E166
BS02 CA A D138 E177 D185 E187 E190 D138 E177 D183 E185 E188
BS03 CA A D57 D59 Q61 D57 D59 Q61
BS04 CA A Y193 T194 I197 D200 Y191 T192 I195 D198
BS05 CA A E177 N183 P184 D185 E190 E177 N181 P182 D183 E188
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ow3, PDBe:4ow3, PDBj:4ow3
PDBsum4ow3
PubMed24633409
UniProtP00800|THER_BACTH Thermolysin (Gene Name=npr)

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