Structure of PDB 4ovz Chain A

Receptor sequence
>4ovzA (length=305) Species: 228330 (SARS coronavirus Urbani) [Search protein sequence]
FTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV
LPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA
DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNK
TVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMY
MGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGT
FLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKE
TSYTT
3D structure
PDB4ovz X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P85 A G164 D165 P249 Y269 Q270 Y274 T302 G156 D157 P241 Y261 Q262 Y266 T294 MOAD: ic50=0.49uM
PDBbind-CN: -logKd/Ki=6.31,IC50=0.49uM
BindingDB: IC50=490nM
BS02 P85 A M209 Y269 M201 Y261 MOAD: ic50=0.49uM
PDBbind-CN: -logKd/Ki=6.31,IC50=0.49uM
BindingDB: IC50=490nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ovz, PDBe:4ovz, PDBj:4ovz
PDBsum4ovz
PubMed24568342
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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