Structure of PDB 4otp Chain A

Receptor sequence
>4otpA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
DPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIYKK
TWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQ
LSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQ
SVEHDHPHALEFLRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHEN
MDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYI
3D structure
PDB4otp Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A I186 S187 V194 K208 P265 I280 X341 I24 S25 V32 K46 P71 I86 X147
BS02 MG A N329 X341 N135 X147
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4otp, PDBe:4otp, PDBj:4otp
PDBsum4otp
PubMed24948609
UniProtQ9BRS2|RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (Gene Name=RIOK1)

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