Structure of PDB 4osp Chain A

Receptor sequence
>4ospA (length=252) Species: 1906 (Streptomyces fradiae) [Search protein sequence]
GKLTGKTALVTGSSRGIGRATAIRLAREGALVAVHCSRNREAADETVATI
EKEGGRAFSVLAELGVPGDVHELFLALERGLKERTDATTLDILVNNAGVM
GGVAPEEVTPELFDRLVAVNAKAPFFIVQRALTLIPDGGRIINISSGLTR
FANPQEVAYAMTKGAMDQLTLHFAKHLGSRNITVNSVGPGITNNGTPVFD
NPEAVAQMAGYSVFNRVGEVTDVADVVAFLAGDDARWITGSYLDASGGTL
LG
3D structure
PDB4osp Structure-based engineering of angucyclinone 6-ketoreductases.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 S147 Y160 K164
Catalytic site (residue number reindexed from 1) G16 S146 Y159 K163
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G13 R16 G17 I18 H36 C37 S38 E64 L65 N97 V100 R116 I145 S147 Y160 K164 P190 T193 N195 G12 R15 G16 I17 H35 C36 S37 E63 L64 N96 V99 R115 I144 S146 Y159 K163 P189 T192 N194
BS02 2V4 A M101 S147 G148 L149 F152 I192 M100 S146 G147 L148 F151 I191
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:4osp, PDBe:4osp, PDBj:4osp
PDBsum4osp
PubMed25200607
UniProtK0IB23

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