Structure of PDB 4oqr Chain A

Receptor sequence
>4oqrA (length=386) Species: 31958 (Amycolatopsis orientalis) [Search protein sequence]
PVTLPTGRAVGYPFDPPPDLVKLPPVSPMRFPDGHIGWLVTSHAAARTVM
IDPRFSNRPEHKHPVFSVIPRPAPAPGWFTNMDAPEHTRYRRMLISQFTV
RRIKELEPRIVRITEDHLDAMAKAGPPVDLVQAFALPVPSLVICELLGVS
YADHAFFQEQTTIMVSVDKTQDEVTTALGKLTRYIAELVATKRLSPKDDL
LGSLITDTDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIAN
LDSPDAVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAV
NRDPKVFDEPDILQLDRVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRL
FARFPSLRLAVPAEEIKLREKSAAYGVWALPVAWDA
3D structure
PDB4oqr Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.
ChainA
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S181 A240 E243 T244 T245 H283 C348 L349 G350 E357 A389
Catalytic site (residue number reindexed from 1) S166 A225 E228 T229 T230 H268 C333 L334 G335 E342 A374
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A F94 H102 R106 L237 A240 T244 T245 P287 R289 A340 F341 H346 C348 L349 G350 A354 F79 H87 R91 L222 A225 T229 T230 P272 R274 A325 F326 H331 C333 L334 G335 A339
BS02 2UO A F76 P80 V180 A240 A388 F66 P70 V165 A225 A373 MOAD: Kd=29.3uM
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4oqr, PDBe:4oqr, PDBj:4oqr
PDBsum4oqr
PubMed25691737
UniProtW5VH56

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