Structure of PDB 4oqe Chain A

Receptor sequence
>4oqeA (length=239) Species: 1906 (Streptomyces fradiae) [Search protein sequence]
QADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHSPAASLLDVACGT
GMHLRHLADSFGTVEGLELSADMLAIARRRNPDAVLHHGDMRDFSLGRRF
SAVTCMFSSIGHLAGQAELDAALERFAAHVLPDGVVVVEPWWFPENFTPG
YVAAGTVEAGGTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEESHR
ITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLPGA
3D structure
PDB4oqe Production of a novel N-monomethylated dideoxysugar.
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.235: dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y14 Y22 Y33 A58 H64 E79 L80 D101 M102 S120 Y4 Y12 Y23 A47 H53 E68 L69 D90 M91 S109
BS02 MMF A Y14 K29 F118 W152 W153 N157 F158 T159 Y162 R177 S179 S181 R241 Y4 K19 F107 W141 W142 N146 F147 T148 Y151 R166 S168 S170 R230
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0009058 biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4oqe, PDBe:4oqe, PDBj:4oqe
PDBsum4oqe
PubMed24512254
UniProtP95748|TYLM1_STRFR dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (Gene Name=tylM1)

[Back to BioLiP]