Structure of PDB 4oq5 Chain A

Receptor sequence
>4oq5A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
MDLYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRVTLISFGA
FVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
3D structure
PDB4oq5 Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
ChainA
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2UU A M231 L235 M250 V253 R263 T266 L267 F270 M60 L64 M79 V82 R92 T94 L95 F98 PDBbind-CN: -logKd/Ki=6.30,IC50=0.5uM
BindingDB: IC50=500nM
BS02 2UU A A227 G230 M231 A56 G59 M60 PDBbind-CN: -logKd/Ki=6.30,IC50=0.5uM
BindingDB: IC50=500nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4oq5, PDBe:4oq5, PDBj:4oq5
PDBsum4oq5
PubMed24582986
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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