Structure of PDB 4onc Chain A

Receptor sequence
>4oncA (length=277) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
FPQLPPAPDDYPTFPDTSTWPVVFPELPAAGPCRPPQHTSKAAAPRIPAD
RLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIACGAIELGIKWL
SLYAFSTENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVGSRPR
LWRSVINELAVAEEMTKSNDVITINYCVNYGGRTEITEATREIAREVAAG
RLNPERITESTIARHLQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAEYI
FQDKLWPDYDRRDLWAACEEYASRTRR
3D structure
PDB4onc Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis
ChainA
Resolution1.83 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D76 H93 I187
Catalytic site (residue number reindexed from 1) D61 H78 I172
Enzyme Commision number 2.5.1.86: trans,polycis-decaprenyl diphosphate synthase.
2.5.1.87: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 40B A G77 G79 R80 R89 R127 G62 G64 R65 R74 R112 MOAD: Kd=410nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004659 prenyltransferase activity
GO:0008834 di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030145 manganese ion binding
GO:0033850 Z-farnesyl diphosphate synthase activity
GO:0045547 dehydrodolichyl diphosphate synthase activity
GO:0046872 metal ion binding
GO:0052923 all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
Biological Process
GO:0016094 polyprenol biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4onc, PDBe:4onc, PDBj:4onc
PDBsum4onc
PubMed24475925
UniProtP9WFF7|DPDS_MYCTU Decaprenyl diphosphate synthase (Gene Name=uppS)

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