Structure of PDB 4omc Chain A

Receptor sequence

>4omcA (length=466) Species: 9606 (Homo sapiens)

VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEP
KDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEAN
NYGTLTKFTLVLYGTA

3D structure

• PDB: 4omc X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D153 H194
• Catalytic site (residue number reindexed from 1): D45 H86
• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	D154 H194 V231 E236 W254 G255 D264 Y308	D46 H86 V123 E128 W146 G147 D156 Y200
BS02	peptide	A	S253 W254 G255 P256 D258 A292 D306 T367 S368	S145 W146 G147 P148 D150 A184 D198 T259 S260
BS03	CA	A	D115 D162 V205 N208 V210 G212	D7 D54 V97 N100 V102 G104
BS04	CA	A	D258 D301 E331	D150 D193 E223
BS05	CA	A	D174 D179 D181	D66 D71 D73

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:4omc, PDBe:4omc, PDBj:4omc
• PDBsum: 4omc
• PubMed: 24666235
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)