Structure of PDB 4olf Chain A

Receptor sequence
>4olfA (length=482) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
ILGITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQA
FFNKEIKKLNVENSYFPLFVTKNKLEKIEGFSPEVAWVTKYGDSNLPEEI
AIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPFIRTRE
FLWQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGEKF
GGANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQYV
HQTSWGCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFYKTTDENA
IHSYCKDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIEVGPK
DLQNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKKKLDD
SIVQVTSFSEVMNALNKKKMVLAPWCEDIATEEEIKKETQRLLSGAMKPL
CIPLDQPPMPPNMKCFWSGKPAKRWCLFGRSY
3D structure
PDB4olf Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A R390 E392 R401 T402 F405 Q475 A477 T512 R514 R136 E138 R147 T148 F151 Q221 A223 T258 R260
BS02 HFG A F335 E338 P358 T359 E361 R390 F454 S508 W509 F81 E84 P104 T105 E107 R136 F200 S254 W255
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:4olf, PDBe:4olf, PDBj:4olf
PDBsum4olf
PubMed
UniProtQ8I5R7|SYP_PLAF7 Proline--tRNA ligase (Gene Name=proRS)

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