Structure of PDB 4olc Chain A

Receptor sequence
>4olcA (length=308) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence]
SAGKTVVIALGGNAMLQAKEKGDYDTQRKNVEIAASEIYKIHKAGYKVVL
TSGNGPQVGAIKLQNQAAAGVSPEMPLHVCGAMSQGFIGYMMSQAMDNVF
CANNEPANCVTCVTQTLVDPKDQAFTNPTKPVGRFYTEQEAKDLMAANPG
KILREDAGRGWRVVVPSPRPLEIVEYGVIKTLIDNNVLVICTNGGGIPCK
RENKVISGVDAVIDKDLATSLLAKTLNSDYLMILTDVLNACIRKLEEIKL
SEILALEKDGHFAAGSMGPKVRAAIEFTQATGKMSIITSLSTAVDALNGK
CGTRIIKD
3D structure
PDB4olc Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G13 N14 K131 K216 K278
Catalytic site (residue number reindexed from 1) G12 N13 K130 K215 K270
Enzyme Commision number 2.7.2.2: carbamate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DCD A D237 L239 S299 D236 L238 S291 PDBbind-CN: -logKd/Ki=6.19,IC50=0.64uM
Gene Ontology
Molecular Function
GO:0008804 carbamate kinase activity
GO:0016301 kinase activity
Biological Process
GO:0006525 arginine metabolic process
GO:0016310 phosphorylation
GO:0019546 arginine deiminase pathway
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4olc, PDBe:4olc, PDBj:4olc
PDBsum4olc
PubMed24558036
UniProtA8BB85

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