Structure of PDB 4ol9 Chain A

Receptor sequence
>4ol9A (length=297) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
HMIATGIALVGPGAVGTTVAALLHKAGYSPLLCGHTPRAGIELRRDGADP
IVVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVL
QNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGP
AAEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFR
RDDVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSML
ADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG
3D structure
PDB4ol9 Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K177
Catalytic site (residue number reindexed from 1) K179
Enzyme Commision number 1.1.1.169: 2-dehydropantoate 2-reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G9 P10 G11 A12 V13 G32 H33 T34 A72 V73 K74 Q77 A80 W84 L98 Q99 N100 V122 C124 A126 R255 E258 G11 P12 G13 A14 V15 G34 H35 T36 A74 V75 K76 Q79 A82 W86 L100 Q101 N102 V124 C126 A128 R257 E260
Gene Ontology
Molecular Function
GO:0008677 2-dehydropantoate 2-reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0015940 pantothenate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ol9, PDBe:4ol9, PDBj:4ol9
PDBsum4ol9
PubMed
UniProtP9WIL1|PANE_MYCTU 2-dehydropantoate 2-reductase (Gene Name=Rv2573)

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