Structure of PDB 4ol8 Chain A

Receptor sequence
>4ol8A (length=390) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PVWLQQKYREIIRNDLPPPVKHDIEIKPGARLPRLQPYHVTEKNEQEINK
IVQKLLDNKFIVPSKSPCSSPVVLVPKTFRLCVDYRTLNKATISDPFPLP
RIDNLLSRIGNAQIFTTLDLHSGYHQIPMEPKDRYKTAFVTPSGKYEYTV
MPFGLVNAPSTFARYMADTFRDLRFVNVYLDDILIFSESPEEHWKHLDTV
LERLKNENLIVKKKKCKFEETEFLGYSIGIQKIAPLQHKCAAIRDFPTPK
TVKQAQRFLGMINYYRRFIPNCSKIAQPITEKQDKAIDKLKDAPFNNKAN
YRLTTDASKDGIGAVLEEVDNKNKLVGVVGYFSKSLEYPAGELELLGIIK
ALHHFRYMLHGKHFTLRTNHARRVQRWLDDLATYDFTLEY
3D structure
PDB4ol8 Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A C114 V115 R118 F185 G186 V188 P191 N297 C82 V83 R86 F153 G154 V156 P159 N263
BS02 dna A Y211 D213 L258 G259 K287 Q290 R291 G294 M295 Y298 R445 Y179 D181 L224 G225 K253 Q256 R257 G260 M261 Y264 R376
External links
PDB RCSB:4ol8, PDBe:4ol8, PDBj:4ol8
PDBsum4ol8
PubMed24608367
UniProtQ99315|YG31B_YEAST Transposon Ty3-G Gag-Pol polyprotein (Gene Name=TY3B-G)

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