Structure of PDB 4okz Chain A

Receptor sequence
>4okzA (length=346) Species: 457429 (Streptomyces pristinaespiralis ATCC 25486) [Search protein sequence]
ELTVPPLFSPIRQAIHPKHADIDVQTAAWAETFRIGSEELRGKLVTQDIG
TFSARILPEGREEVVSLLADFILWLFGVDDGHCEEGELGHRPGDLAGLLH
RLIRVAQNPEAPMMQDDPLAAGLRDLRMRVDRFGTAGQTARWVDALREYF
FSVVWEAAHRRAGTVPDLNDYTLMRLYDGATSVVLPMLEMGHGYELQPYE
RDRTAVRAVAEMASFIITWDNDIFSYHKERRGSGYYLNALRVLEQERGLT
PAQALDAAISQRDRVMCLFTTVSEQLAEQGSPQLRQYLHSLRCFIRGAQD
WGISSVRYTTPDDPANMPSVFTDVPTDDSTEPLDIPAVSWWWDLLA
3D structure
PDB4okz Induced-fit mechanism in class i terpene cyclases.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L78 F79 D82 E88 R163 R178 G182 N224 S228 K231 E232 S236 W304 G305 R310
Catalytic site (residue number reindexed from 1) L75 F76 D79 E85 R160 R175 G179 N221 S225 K228 E229 S233 W301 G302 R307
Enzyme Commision number 4.2.3.181: selina-4(15),7(11)-diene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D82 E87 D79 E84
BS02 MG A N224 S228 E232 N221 S225 E229
BS03 3E9 A F55 L78 F79 D82 R178 G182 A183 N224 S228 K231 E232 R310 Y311 F52 L75 F76 D79 R175 G179 A180 N221 S225 K228 E229 R307 Y308
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0010333 terpene synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4okz, PDBe:4okz, PDBj:4okz
PDBsum4okz
PubMed24890698
UniProtB5HDJ6|SEDS_STRE2 Selina-4(15),7(11)-diene synthase ((2E,6E)-farnesyl diphosphate cyclizing) (Gene Name=SSDG_02809)

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