Structure of PDB 4okw Chain A

Receptor sequence
>4okwA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSLMGLMVFAMGWRSFTNVNSAMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACSRRFYQLTKLLDSVQPIARELHQFTF
DLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
3D structure
PDB4okw Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V716 K720 Q733 M734 Q738 E893 M894 E897 V46 K50 Q63 M64 Q68 E215 M216 E219
BS02 198 A L704 N705 L707 G708 Q711 M742 M745 V746 M749 F764 T877 M895 I898 I899 L34 N35 L37 G38 Q41 M72 M75 V76 M79 F94 T199 M217 I220 I221 BindingDB: IC50=248nM,Ki=509nM
External links
PDB RCSB:4okw, PDBe:4okw, PDBj:4okw
PDBsum4okw
PubMed25091737
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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