Structure of PDB 4oks Chain A

Receptor sequence
>4oksA (length=440) [Search protein sequence]
FTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVA
ATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGA
YDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSH
PNIEEVALSTTGEIPFYGKAIPLEVIGRHLIFCHSKKKCDELAAKLVALG
INAVAYYRGLDVSVIPTNGDVVVVSTDALGDFDSVIDCNTCVTQTVDFSL
DPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSV
LCECYDAGCAWYELMPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLT
HIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKP
TLHGPTPLLYRLGAVQNEVTLTHPITKYIMTCMSADLEVV
3D structure
PDB4oks Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2T9 A V232 T254 G255 T269 G271 K272 A275 T298 A497 W501 Y502 V49 T71 G72 T86 G88 K89 A92 T115 A307 W311 Y312 MOAD: Kd=33uM
PDBbind-CN: -logKd/Ki=4.48,Kd=33uM
BS02 CA A D437 E447 D247 E257
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4oks, PDBe:4oks, PDBj:4oks
PDBsum4oks
PubMed24467709
UniProtK4KA16

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