Structure of PDB 4ok5 Chain A

Receptor sequence
>4ok5A (length=441) [Search protein sequence]
FTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVA
ATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGA
YDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSH
PNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVA
LGINAVAYYRGLDVSVIPDVVVVSTDALMTTGDFDSVIDCNTCVTQTVDF
SLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDS
SVLCECYDAGCAWYELMPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTG
LTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRL
KPTLHGPTPLLYRLGAVQNEVTLTHPITKYIMTCMSADLEV
3D structure
PDB4ok5 Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D437 E447 D249 E259
BS02 2T2 A V232 G255 T269 G271 K272 A275 A297 T298 A497 W501 Y502 V49 G72 T86 G88 K89 A92 A114 T115 A309 W313 Y314 MOAD: ic50=31uM
PDBbind-CN: -logKd/Ki=4.51,IC50=31uM
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4ok5, PDBe:4ok5, PDBj:4ok5
PDBsum4ok5
PubMed24467709
UniProtK4KA16

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