Structure of PDB 4ok3 Chain A

Receptor sequence
>4ok3A (length=426) [Search protein sequence]
NSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATL
GFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDI
IICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNI
EEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLNAVAS
VIPDVVVVSTDALMTGGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQ
DAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYE
LMPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQS
GENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLG
AVQNEVTLTHPITKYIMTCMSADLEV
3D structure
PDB4ok3 Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2SY A V232 G255 T269 G271 K272 A275 A297 T298 A497 W501 Y502 V46 G69 T83 G85 K86 A89 A111 T112 A294 W298 Y299 MOAD: ic50=71uM
PDBbind-CN: -logKd/Ki=4.15,IC50=71uM
BS02 CA A D437 E447 D234 E244
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4ok3, PDBe:4ok3, PDBj:4ok3
PDBsum4ok3
PubMed24467709
UniProtK4KA16

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