Structure of PDB 4oj9 Chain A

Receptor sequence
>4oj9A (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPI
ARELHQFAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB4oj9 Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
ChainA
Resolution3.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V713 V730 Q733 M734 I737 Q738 M894 E897 V44 V61 Q64 M65 I68 Q69 M225 E228
BS02 HFT A L704 N705 L707 G708 Q711 M745 V746 M749 R752 F764 L35 N36 L38 G39 Q42 M76 V77 M80 R83 F95 BindingDB: IC50=26nM,Ki=43nM
External links
PDB RCSB:4oj9, PDBe:4oj9, PDBj:4oj9
PDBsum4oj9
PubMed25091737
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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