Structure of PDB 4oh6 Chain A

Receptor sequence
>4oh6A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFA
FDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
3D structure
PDB4oh6 Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
ChainA
Resolution3.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V713 V716 Q733 M734 I737 Q738 E893 E897 V43 V46 Q63 M64 I67 Q68 E216 E220
BS02 HFT A L704 N705 L707 Q711 M742 M745 V746 M749 R752 F764 L873 L34 N35 L37 Q41 M72 M75 V76 M79 R82 F94 L196 BindingDB: IC50=26nM,Ki=43nM
External links
PDB RCSB:4oh6, PDBe:4oh6, PDBj:4oh6
PDBsum4oh6
PubMed25091737
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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