Structure of PDB 4oh5 Chain A

Receptor sequence

>4oh5A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]

PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFA
FDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

3D structure

PDB

4oh5 Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	V716 K720 Q733 M734 Q738 M894 E897	V46 K50 Q63 M64 Q68 M217 E220
BS02	HFT	A	L704 N705 G708 Q711 M745 V746 M749 F764	L34 N35 G38 Q41 M75 V76 M79 F94	BindingDB: IC50=26nM,Ki=43nM

External links

PDB	RCSB:4oh5, PDBe:4oh5, PDBj:4oh5
PDBsum	4oh5
PubMed	25091737
UniProt	P10275\|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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