Structure of PDB 4ogc Chain A

Receptor sequence
>4ogcA (length=883) Species: 1115803 (Actinomyces naeslundii str. Howell 279) [Search protein sequence]
SAHHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGSAVSRVA
PDPLPGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGENRPLTADERR
HVVTFLTEDSQADLTWVDVAEKLGVHRRDLRGTRSAARPPIDATDRIMRQ
TKISSLKTWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPEEDQAKLD
SLHLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEA
INAPVGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMAD
ERDKANRRRYNDNQEAMKKIQRDYGKEGYISRGDIVRLDALELQGCACLY
CGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSNTPFAVWA
QKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLRRTQEDP
EIDERSMESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSR
INLIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTG
KEQTWKQYTGSTVGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRL
RLSDGNAHTVNPSKLVSHRLGDGLTVQQIDRACTPALWCALTREKDFDEK
NGLPAREDRAIRVHGHEIKSSDYIQVFSKRKKTDSDRDETPFGAIAVRGG
FVEIGPSIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLFSAVIPPQS
ISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDF
PNTTRWRICGYDTNSKLTLKPIVLAAEGLENPSSAVNEIVELKGWRVAIN
VLTKVHPTVVRRDALGRPRYSSRSNLPTSWTIE
3D structure
PDB4ogc Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C566 C569 C602 C605 C348 C351 C384 C387
BS02 MN A D17 H736 D10 H518
BS03 MG A Q586 G588 G590 Q368 G370 G372
BS04 MG A D581 N606 D363 N388
BS05 MN A D17 E505 D10 E287
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4ogc, PDBe:4ogc, PDBj:4ogc
PDBsum4ogc
PubMed24505130
UniProtJ3F2B0|CAS9_ACTNH CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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