Structure of PDB 4og8 Chain A

Receptor sequence
>4og8A (length=469) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPGPVLTFQSEKMKGMKELLVATK
INSSAIKLQLTAQSQVQMK
3D structure
PDB4og8 High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TBF A S154 S155 S133 S134
BS02 2SF A S178 H181 F238 A242 M278 Y319 M322 Y323 E363 S157 H160 F217 A221 M257 Y298 M301 Y302 E342 MOAD: ic50=56nM
PDBbind-CN: -logKd/Ki=7.25,IC50=56nM
BindingDB: Kd=110000nM,IC50=67nM,Ki=58nM
BS03 PGA A W126 K135 W105 K114
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4og8, PDBe:4og8, PDBj:4og8
PDBsum4og8
PubMed24472025
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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