Structure of PDB 4og5 Chain A

Receptor sequence
>4og5A (length=469) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPAPVLTFQSEKMKGMKELLVATK
INSSAIKLQLTAQSQVQMK
3D structure
PDB4og5 High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
ChainA
Resolution1.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2S7 A S155 S178 H181 F238 C241 A242 Y319 M322 Y323 E363 S134 S157 H160 F217 C220 A221 Y298 M301 Y302 E342 MOAD: ic50=302nM
PDBbind-CN: -logKd/Ki=6.52,IC50=302nM
BindingDB: IC50=195nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4og5, PDBe:4og5, PDBj:4og5
PDBsum4og5
PubMed24472025
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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