Structure of PDB 4ofu Chain A

Receptor sequence
>4ofuA (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFT
FDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB4ofu Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
ChainA
Resolution2.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V716 K720 Q733 M734 I737 Q738 E893 E897 V46 K50 Q63 M64 I67 Q68 E216 E220
BS02 DHT A L704 N705 Q711 F764 T877 L34 N35 Q41 F94 T200 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
External links
PDB RCSB:4ofu, PDBe:4ofu, PDBj:4ofu
PDBsum4ofu
PubMed25091737
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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