Structure of PDB 4ofe Chain A

Receptor sequence
>4ofeA (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
WTPPRSPFNLVQETLFHDPWKLLIATIFLNKTSGKMAIPVLWKFLEKYPS
AEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGI
GKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
3D structure
PDB4ofe Structure of R468K/D560N MBD4 bound to G:T mispair DNA
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L447 Q449 L466 N467 K468 S470 H535 G536 I537 G538 Y540 G541 N560 K562 L10 Q12 L29 N30 K31 S33 H98 G99 I100 G101 Y103 G104 N123 K125
BS02 dna A K468 K472 M473 P505 G507 L508 Y509 D510 L511 K31 K35 M36 P68 G70 L71 Y72 D73 L74
BS03 MG A I532 L534 I537 I95 L97 I100
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4ofe, PDBe:4ofe, PDBj:4ofe
PDBsum4ofe
PubMed
UniProtO95243|MBD4_HUMAN Methyl-CpG-binding domain protein 4 (Gene Name=MBD4)

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