Structure of PDB 4oez Chain A

Receptor sequence

>4oezA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]

QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQF
TFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT

3D structure

PDB

4oez Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	V716 K720 Q733 M734 I737 Q738 E893 M894 E897	V47 K51 Q64 M65 I68 Q69 E217 M218 E221
BS02	DHT	A	L701 L704 N705 Q711 M745 M749 F764 T877	L32 L35 N36 Q42 M76 M80 F95 T201	BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM

External links

PDB	RCSB:4oez, PDBe:4oez, PDBj:4oez
PDBsum	4oez
PubMed	25091737
UniProt	P10275\|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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