Structure of PDB 4oex Chain A

Receptor sequence
>4oexA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
MEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLN
LVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGK
IQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSIMEHHHFDQCLMILN
SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQF
NLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGKNKI
PSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ
3D structure
PDB4oex Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5EO A V782 F786 M816 Q817 F820 V238 F242 M253 Q254 F257 MOAD: Kd=0.000000064M
PDBbind-CN: -logKd/Ki=5.84,Kd=1.45uM
BindingDB: Kd=1500nM
BS02 ZN A H617 H653 D654 D764 H84 H120 D121 D220
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4oex, PDBe:4oex, PDBj:4oex
PDBsum4oex
PubMed24702184
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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